Dual‐Targeted Nanoreactors and Prodrugs: Hydrogen Peroxide Triggers Oxidative Damage and Prodrug Activation for Synergistic Elimination of Cancer Cells

Synergistic strategies by combining nanoreactors and prodrugs hold tremendous potential in anticancer treatment. However, precise death of target cancer cells remains a significant challenge due to the absence an elaborate targeting strategy. Here, dual-targeting approach that combines action H2O2-producing folate receptor-targeted with cyclooxygenase-2 (COX-2) targeted prodrug is reported. A folate-modified silica nanoreactor encapsulating glucose oxidase (GOX) prepared generate H2O2, which induces oxidative stress allows activation intracellular delivery. novel bearing both COX-2 Celecoxib SN-38 agent H2O2-cleavable thioketal linker activate drug presented. By dual-targeting, generated H2O2 from GOX triggers cleavage produce active form inducing synergistic cell death. This strategy potency can aid developing selective effective therapeutics.